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  1. HCC causes acute disaster of abdominal by bleeding intra-abdominal or extra hepatic appearance.[6] Also, patients have HCC with cirrhosis cause palmarerythema, obstractive jaundice, gynecomastia and portal hypertension.[7,8] HCC is associated with hypoglycemia, erythrocytosis, hypercalcemia, hypercholesterolemia and diarrhea.[9] The distributions of HCC are largely result from various risk factors particularly the majority of hepatitis B and C viral infection and alcoholic liver disease.[10] Chronic HBV infection cause of HCC in different area, where the virus is largely endemic and vertical transmission common.[11,12] High alcohol consumption; smoking of cigarette; obesity; and diabetes have also been associated with an increased risk of developing HCC.[13-15] Previous studies have reported a close correlation with obesity and diabetes and an increased risk of HCC progression.[16] Also, there are common environmental factor associated with HCC development such as aflatoxin, a product of the Aspergillus fungus.[17] Several physiological disorders of the liver have been implicated in the HCC development, including α-1 antitrypsin deficiency; certain porphyrias; Olchi's disease; and hereditary hemachromatosis, each typically in the setting of cirrhosis.[18] Additionally, an automimmune disorders have been implicated in HCC pathogenesis, including primary biliary cirrhosis and autoimmune hepatitis.[19] HCC majority occurs in the setting of liver cirrhosis.